The 2CA-Braga is a Clinical Research Centre, located in the city of Braga, Portugal. It is a unique combination between the University of Minho (UM) and Hospital de Braga (HB), with a focus on research, clinical care, education and training. The 2CA-Braga is closely connected with the Life and Health Sciences Research Institute (ICVS-3Bs) and the School of Health Sciences (ECS) within the University of Minho. To strengthen and lead this non-profit partnership, considering the recognised capabilities in bioscience innovation and translational research of the several partners, the 2CA-Braga aims to promote with Hospital de Braga and Hospital CUF Porto the maintenance of health and, most importantly, contribute to add quality of life through innovative breakthroughs. The 2CA-Braga is now within three years of life and this Newsletter aims to provide some insight on the clinical research centre activities within this period along with additional actions planned for the future. We hope you enjoy the reading!